Extracellular vesicles

Proteome analysis


Extracellular vesicles are an essential source to study cell communication and other biological processes, and they are naturally released from most cell types. Various subtypes of extracellular vesicles have been proposed, such as apoptotic bodies, ectosomes/microvesicles, exosomes, microparticles, and oncosomes, all with unique features. The riches in features and unique insight in communications have made extracellular vesicles an important tool in biomarker discovery.

If you’d like to learn more, we are happy to discuss your project and help you get the most out of your extracellular vesicles.


Let’s discuss your project

Guiding you from sample to biology

Our experts are ready to help you with your project with extraceullar vesicles. Ideally, we set up an online meeting where we get to learn about your project. Here, we discuss the different options to reach your aim.



Get a price estimate within 24 hours

If you need an estimate for your project, we are happy to help. We encourage you to request an initial free consultation to assess which approach best fits your research aim with extracellular vesicles.



By booking a meeting, you agree to our privacy policy.

Sample preparation and Mass Spectrometry

Extracellular vesicles using mass spectrometry

Biogenity has specially optimized Standard Operating Procedures for extracellular vesicles to ensure the best coverage of the proteome in your samples. Complete proteome insight is vital when studying extracellular vesicles to understand the biological functions hereof or discover new disease markers.


Experienced Professionals

Biogenity’s team and its partners works with the highest standards to ensure the best quality handling and analysis of your samples. We collaborate with carefully selected proteomics laboratories for extraceullular vesicles, ensuring that every aspect of the workflow is executed by specialized personnel.

The latest equipment from Thermo Fisher Scientific

We pride ourselves on being able to offer the latest equipment on the market. Biogenity offers the latest equipment from Thermo Fischer, ensuring a deep coverage. If you’d like to see the complete platform list, follow this link.



Protein modifications with LC-MS/MS

Post-translational modifications have shown great importance in the function and biogenesis of extracellular vesicles. Acetylation, N-glycosylation, Methylation, Phosphorylation, and Ubiquitylation are some of the most researched modifications in extracellular vesicles biology. Biogenity have incredible laboratory partners, enabling us to offer you complete workflows to study these modifications.

Data analysis, including report, figures, and tables

Visualisation of your extracellular vesicles

Data analysis is where you get your overview. You will receive an easy-to-follow report describing the data analysis on your extracellular vesicles and results hereof, step-by-step, together with a folder containing all tables and figures. To ensure that you have the material needed, we always provide a vast number of figures and tables.



Let us be your data scientist

Biogenity’s data analysis is much more than simply a data analysis. It offers an insight into what biology is, e.g., potentially activated or deactivated in the different conditions, without the hassle of postprocessing the data. Our team does it all: data filtration, outlier testing, variance plotting with PCA, clustering, and the statistics - and that is just with the statistical data analysis.


Download DEMO
Characterisation of subgroups

Characterize your sample subgroups' extracellular vesicles with Biogenity's cluster data analysis and statistics, investigating how unique and similar the content is and how the quantities differ.


Function of extracellular vesicles' cargo

Discover the function of your extracellular vesicles' cargo with Biogenity's bioinformatics. In this data analysis, we investigate your enriched molecular functions and pathways.


Customized machine learning models

If you have many samples, you might have enough data to generate predictive models. Biogenity's team consists of machine- and deep learning experts, ready to integrate and develop models, e.g., for disease state prediction or cell origin.

Interactive plots to highlight signaling pathways

With our bioinformatic data analysis, you will also get interactive plots that allow you to explore the signaling pathways that are enriched in your data. It lets you take the regulated proteins into perspective, showing which biological pathways or biological processes are potentially up or down-regulated. This helps you get a good understanding of what is happening in the different conditions.

Delivery and discussion

Delivered directly to your inbox

When your extracellular vesicles analysis is ready, we deliver it directly to your inbox. Your data and reports are easy to access and secured with encryption and password protection.

You can receive your sample leftovers sent by courier, or Biogenity can safely destroy them after project completion. It is entirely up to you.



Plant a tree with Biogenity and One Tree Planted

Partnering with One Tree Planted, we want to work towards a brighter future with better treatment for diseases and a healthy planet to enjoy life. For us, our children, grandchildren, and the generations to come.

Biogenity donates a dozen trees for every project delivered to support local communities, reforestation in the Amazon rainforest, and reduce CO2 emissions. See how we are making a difference together.

Post-consultation and discussion

It is important to us that you get the most out of your experiment, which is why we always offer a post-consultation where you can ask all your questions about the results. Together, we ensure that you have the best prerequisite for your further research. The consultation can also be used to explore the next step, whether you are looking to expand the project with additional omics studies or validate the results.

What you can expect:

  • Explanation of the different steps in the sample analysis
  • Discussion of the data
  • Explanation of the different steps in the data analysis
  • Q&A to the report

Interpretation of your biological findings

If you need help interpreting the proteomic findings, or a third-party interpretation, Biogenity's consultants are ready to assist you. Click "play" and meet one of our consultants.

Our interpretational analysis highlights strengths and limitations in the experimental design and conclusions, allowing us to recommend follow-up experiments, publication strategies, reporting, and more.


Learn more

Other proteomics LC-MS/MS approaches

Cerebrospinal fluid

Proteomics

When investigating treatment effects or searching for biomarkers in Cerebrospinal fluid, Biogenity provides the tool to explore the proteome.

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Plasma

Proteomics

Biogenity can provide you with up to 2,000 proteins in your study if you need a high through-put proteomic service with deep coverages.

Learn more
Fermentation products

Proteomics

If you want to improve or understand bioactive molecule production from the fermentation, Biogenity offers proteome analysis for your fermentation products.

Learn more
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