LC-MS Proteomics

Proteome analysis


At Biogenity, we’re at the forefront of providing state-of-the-art LC-MS to empower researchers with the ability to generate proteomics-based biological insight.

LC-MS is a versatile platform that allows the discovery of biomarkers, the investigation of biological systems, and the addressing of protein concentration and post-translational modifications. LC-MS is unlike many other proteomic workflows; it is not dependent on antibodies or aptamers, which allows for the analysis of much more diverse proteins and makes experimental designs more customizable.

Biogenity provides expertise and experience, allowing you to get the right LC-MS approaches for your research aim.

What sets LC-MS apart:

  • Relative and absolute quantification: Absolute quantification can be achieved using isotope-labeled peptides, whereas, without these, quantification would be relative.
  • Highly customizable dynamic ranges: Adjusting the dynamic ranges allows you to get the depth needed for your study and adjust the price points accordingly.
  • Compatible with most genome-annotated species: Proteome-based discovery studies depend only on a protein sequence database to annotate analyzed protein content when proteins have been extracted LC-MS.
  • Adaptable to fasta files from genomics and transcriptomic experiments: Whether you are investigating cancer subgroups, species variants, or just sequenced a novel organism, your results from genomics or transcriptomics can be used to enable a tailored proteome annotation.
  • Identify and quantify post-translational modifications: LC-MS can identify and quantify many post-translational modifications to proteins, and some, like phosphorylation, have specialized enrichment methods allowing for improved coverages.

Let’s discuss your project

Guiding you from sample to biology

Our team of experts is well-equipped to assist you with your discovery-based LC-MS proteomics project. We propose initiating the collaboration with an online meeting, during which we can delve into the specifics of your project. The meeting allows us to gain valuable insights into the requirements connected to the objectives. Together, we can explore various options tailored to achieving your goals.



Get a price estimate within 24 hours

If you need an estimate for your project, we are happy to help. We encourage you to request a free consultation to assess which discovery approach fits your proteomics research aim.


Sample preparation and sample analysis

Customized sample preparation for your proteomics

Discover how different methods allow for various proteomic approaches, whether you are looking for label-free proteomics, TMT-based proteomics, clinical proteomics, targeted proteomics, or phosphoproteomics.



Experienced professionals

At Biogenity, our dedicated team is committed to handling your samples carefully. We offer both partial and complete sample preparation workflows and are transparent, thus sharing our protocols. While we encourage transparency and in-house sample preparation, we highly recommend entrusting Biogenity with the sample preparation to minimize potential variance.

More than 10,000 protein identifications for discovery

At Biogenity, we offer a range of sample analysis options tailored to your needs, and our experts will assist you in selecting the most suitable approach. Our options span from budget-friendly choices to cutting-edge deep proteome coverages, with the potential for over 10,000 protein identifications based on sample types.



Advanced Proteomic Analysis with Orbitrap and Q Exactive

We conduct both Data-dependent and Data-independent proteomic analyses utilizing advanced mass spectrometers, including the Orbitrap Exploris 480, Orbitrap Eclipse Tribrid, and Q Exactive Classic, all sourced from Thermo Fisher Scientific.

Data analysis, including report, figures, and tables

From biomarker discovery to data validation

Data analysis is where you get the overview of your LC-MS-based proteome analysis. You will receive an easy-to-follow report describing the data analysis and results hereof, step-by-step, together with a folder containing all tables and figures. To ensure that you have the material needed, we always provide a vast number of figures and tables.



Your dedicated data scientist

Biogenity’s data analysis is much more than simply a data analysis. It offers an insight into what biology is, e.g., potentially activated or deactivated in the different conditions, without the hassle of postprocessing the data. Our team does it all: data filtration, outlier testing, variance plotting with PCA, clustering, and the statistics - and that is just with the statistical data analysis.


Download DEMO

Delivery and discussion

Delivered directly to your inbox

When your LC-MS-based analysis is ready, we deliver it directly to your inbox. Your data and reports are easy to access and secured with encryption and password protection.



Plant a tree with Biogenity and One Tree Planted

Partnering with One Tree Planted, we want to work towards a brighter future with better treatment for diseases and a healthy planet to enjoy life. For us, our children, grandchildren, and the generations to come.

Biogenity donates a dozen trees for every project delivered to support local communities, reforestation in the Amazon rainforest, and reduce CO2 emissions. See how we are making a difference together.

Post-consultation and discussion

It is important to us that you get the most out of your LC-MS-based experiment, which is why we always offer a post-consultation where you can ask all your questions about the results. Together, we ensure that you have the best prerequisite for your further research. The consultation can also be used to explore the next step, whether you are looking to expand the project with additional omics studies or validate the results.

What you can expect:

  • Explanation of the different steps in the sample analysis
  • Discussion of the data
  • Explanation of the different steps in the data analysis
  • Q&A to the report

Other proteomics approaches

Olink-based proteomics

Proteomics

Olink provides comprehensive global protein analysis of your samples, achieving extensive proteome coverage with unparalleled precision.

Olink-based proteomics

Degradomics

Proteomics

Biogenity's degradomics workflows are ideal if you want to investigate or identify protease activity or cleavages sites.

Degradomics

Phosphoproteomics

Proteomics

Biogenity can provide you with deep coverage and an easy-to-follow report if you are interested in kinase activity and phosphorylation patterns.

Phosphoproteomics
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