Biological Fluids Proteomics

Precision Proteomics Services


At Biogenity, we perform deep proteome analysis of biological fluids to uncover clinically relevant biomarkers and gain insight into disease mechanisms despite the high dynamic range of abundant proteins.

Biological fluids such as blood, serum, plasma, cerebrospinal fluid, synovial fluid, urine, etc., are important sources for information. These sample types are being heavily investigated to find, e.g., diagnostic and prognostic markers for various diseases. Common for most biological fluids is that a small range of proteins takes up 95% of the concentration, e.g., serum albumin in plasma and serum. Yet, with state-of-the-art methods and instruments, we can identify up to 2,000 proteins with a deep proteome analysis.

If you’d like to learn more, we are happy to discuss your project and help you get the most out of your biological fluid proteomics analysis.


Let’s discuss your project


800–1,200 proteins
commonly identified in plasma


Up to 150 targets
in targeted fluid assays


Depletion methods
for low-abundance proteins

Guiding you from sample to biology

At Biogenity, we understand that biological fluid proteomics research is a sophisticated field that demands precision, expertise, and a tailored approach. Our team of proteomics experts is dedicated to guiding you through every step of your study, ensuring your project not only succeeds but also contributes to your scientific venture.



Get a free consultation

We invite you to an online consultation, during which we can address your questions and offer an expert assessment of how our biological fluid proteomics strategies can be customized to meet your research goals.


Sample preparation and sample analysis

Sample preparation for biological fluids

Biogenity can apply different techniques to your workflow depending on the research aim. We can help you explore the various opportunities and discuss how the different approaches for analyzing biological fluids using mass spectrometry contribute to answering your research question.

Our laboratory is well-experienced with most biological fluids and has Standard Operating Procedures for extracting the proteome. A depletion method is often applied to ensure the detection of low abundance proteins, which allows for a more comprehensive dynamic range.

Up to 1,200 proteins in a plasma sample

Our Thermo Fisher Scientific instruments and optimized workflow ensure deep proteome coverage. We commonly identify 800-1,200 proteins in a plasma sample. Our laboratory also offers targeted methods for biological fluids, where a selection of up to 150 protein targets can be investigated with increased accuracy and sensitivity.

Whether you need broad discovery in plasma, serum or cerebrospinal fluid, or focused quantification of selected biomarkers, we help you choose the approach that fits your aim and budget.

Data analysis, including report, figures, and tables

Data analysis of biological fluids

Data analysis is where you get your overview. You will receive an easy-to-follow report describing the data analysis of your biological fluid proteomics samples and results hereof, step-by-step, together with a folder containing all tables and figures. To ensure that you have the material needed, we always provide a vast number of figures and tables.



Biomarkers in their biological context

Biogenity’s data analysis highlights the regulated proteins in your biological fluid samples and places them in a biological context with pathway and process analysis, supporting biomarker discovery and the study of disease mechanisms.

Delivery and discussion

Delivery, post-consultation and discussion

At the conclusion of your biological fluid proteomics analysis, we ensure a seamless transition from discovery to application. We deliver detailed reports and data, followed by a post-delivery consultation to discuss your study's insights and findings.


What to expect during post-consultation:

  • Explanation of the different steps in the sample analysis
  • Discussion of the data
  • Explanation of the different steps in the data analysis
  • Q&A to the report(s)

Together, we ensure that you have the best prerequisite for your further research. The consultation can also be used to explore the next step, whether you are looking to expand the project with additional omics studies or validate the results.


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