Laser microdissection for proteomics

Precision Proteomics Services


At Biogenity, we utilize laser microdissection to isolate precise tissue regions, enabling highly controlled sampling and reducing biological variance for deeper molecular insights.

Laser microdissection is a powerful tool to generate homologous samples, and it is often used on tissue samples. Tissue is heterogeneous and can consist of various compartments and cell types. The complexity increases the variance, which can make sample group comparison and time studies difficult.

By extracting, e.g., specific compartments, we can make our samples more homologous and reduce the variance, increasing our chance of discovering the effects we are studying. The challenge of Laser microdissection samples is naturally the small sample size, which is why we use specific methods for extracting and analyzing the proteome hereof.

If you’d like to learn more, we are happy to discuss your project and help you get the most out of your laser microdissected proteomics analysis.


Let’s discuss your project


≈3,000 proteins
from 10⁶ micron samples


Orbitrap Eclipse
state-of-the-art sensitivity


TMT option
MS3-level quantification

Guiding you from sample to biology

At Biogenity, we understand that laser microdissection is a sophisticated field that demands precision, expertise, and a tailored approach. Our team of proteomics experts is dedicated to guiding you through every step of your study, ensuring your project not only succeeds but also contributes to your scientific venture.



Get a free consultation

We invite you to an online consultation, during which we can address your questions and offer an expert assessment of how our proteomics laser microdissection strategies can be customized to meet your research goals.


Sample preparation and sample analysis

Specialized workflows for laser microdissection

At Biogenity, we provide expertise in analyzing low sample sizes, and are well experienced working with laser microdissection samples. We provide you with cutting-edge methods, results, and a data analysis tailored to your complex studies, ensuring you the most value for your samples.

Laser microdissection is a complicated technique, which most don’t have in-house. Besides analyzing your samples, we can assist you with the laser microdissection, cutting out precisely the area of your interest.

3000 proteins from micron of samples

Laser microdissection samples are small, and extracting the proteome is a difficult task. We are proud to say that our collaborating laboratory, in a study of 10^6 micron samples, have detected around 3,000 proteins.

Sensitivity is essential when working with laser microdissection. With Biogenity, your samples will be analyzed on the latest generation of Thermo fisher's instrument, the Orbitrap Eclipse, ensuring state-of-the-art sensitivity. With a TMT option, we can increase the accuracy by performing the quantification on the MS3 level.

Data analysis, including report, figures, and tables

Visualisation of your tissue samples

Data analysis is where you get the overview of your laser microdissected protein analysis. You will receive an easy-to-follow report describing the data analysis and results hereof, step-by-step, together with a folder containing all tables and figures. To ensure that you have the material needed, we always provide a vast number of figures and tables.



Let us be your data scientist

Biogenity’s data analysis is much more than simply a data analysis. It offers an insight into what biology is, e.g., potentially activated or deactivated in the different conditions, without the hassle of postprocessing the data. Our team does it all: data filtration, outlier testing, variance plotting with PCA, clustering, and the statistics - and that is just with the statistical data analysis.

Delivery and discussion

Delivery, post-consultation and discussion

At the conclusion of our laser microdissected proteomics analysis, we ensure a seamless transition from discovery to application. We deliver detailed reports and data, followed by a post-delivery consultation to discuss your study's insights and findings.


What to expect during post-consultation:

  • Explanation of the different steps in the sample analysis
  • Discussion of the data
  • Explanation of the different steps in the data analysis
  • Q&A to the report(s)

Together, we ensure that you have the best prerequisite for your further research. The consultation can also be used to explore the next step, whether you are looking to expand the project with additional omics studies or validate the results.


Get Started Today