Degradomics

Proteome analysis


Degradomics can be an excellent tool for biomarker discovery, drug target validation, and assessing protease biology. Proteases form 5-10% of all drug targets and play a critical role in many diseases. Degradomics provides a specific insight in functional proteomics centered around the degradation of proteins. Here we can identify proteases, monitor activity differences in sample groups, and identify cleavage site specificity, inhibitors, substrate, and interactors.

If you’d like to learn more, we are happy to discuss your project and help you get the most out of your degradomics analysis.


Let’s discuss your project

Guiding you from sample to biology

Our experts are ready to help you with your project with degradomics. Ideally, we set up an online meeting where we get to learn about your project. Here, we discuss the different options to reach your aim.



Get a price estimate for your project

If you need an estimate for your project, we are happy to help. We encourage you to request an initial free consultation to assess which degradomics approach fits your research aim.



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Sample preparation and Mass Spectrometry

Tailored workflows for degradomics

Biogenity offers a mass spectrometry-based degradomics solution, which will be tailored to your projects’ needs and provide a thorough report guiding you through your result. Our team and partners work with the highest standards to ensure the best quality handling and analysis of your samples. Together with Ulrich auf dem Keller’s protease network degradomics, we provide state-of-the-art methods for your project.



Market leading mass spectrometers

Your target can be low or high abundant, depending on the aim of the study. That is why we offer the workflow with various mass spectrometers, ranging from the Q Exactive Classic to the market-leading Eclipse Tribrid. All instruments are Orbitrap-based and from Thermo Fisher Scientific.

Data analysis, including report, figures, and tables

Visualization of your degradomics analysis

Data analysis is where you get the overview of your degradomics analysis. You will receive an easy-to-follow report describing the data analysis and results hereof, step-by-step, together with a folder containing all tables and figures. To ensure that you have the material needed, we always provide a vast number of figures and tables.



Identifying protease and targets with degradomics

With degradomics, you get a data analysis where we perform the quality control and filter the data, providing you with easy access to the relevant data. We also provide you with an overview of proteases and targets as well as make sample group and timepoint comparisons with a wide range of statistical tools to ensure the most power for your comparison. Our bioinformatics analysis retrieves information about our findings and puts your data in their biological setting for you to interpret.

Interactive plots to highlight signaling pathways

With our bioinformatic data analysis, you will also get interactive plots that allow you to explore the signaling pathways that are enriched in your data. It lets you take the regulated proteins into perspective, showing which biological pathways or biological processes are potentially up or down-regulated. This helps you get a good understanding of what is happening in the different conditions.


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Delivery and discussion

Delivered directly to your inbox

When your degradomics analysis is ready, we deliver it directly to your inbox. Your data and reports are easy to access and secured with encryption and password protection.

You can receive your sample leftovers sent by courier, or Biogenity can safely destroy them after project completion. It is entirely up to you.



Plant a tree with Biogenity and One Tree Planted

Partnering with One Tree Planted, we want to work towards a brighter future with better treatment for diseases and a healthy planet to enjoy life. For us, our children, grandchildren, and the generations to come.

Biogenity donates a dozen trees for every project delivered to support local communities, reforestation in the Amazon rainforest, and reduce CO2 emissions. See how we are making a difference together.

Post-consultation and discussion

It is important to us that you get the most out of your experiment, which is why we always offer a post-consultation where you can ask all your questions about the results. Together, we ensure that you have the best prerequisite for your further research. The consultation can also be used to explore the next step, whether you are looking to expand the project with additional omics studies or validate the results.

What you can expect:

  • Explanation of the different steps in the sample analysis
  • Discussion of the data
  • Explanation of the different steps in the data analysis
  • Q&A to the report

Other proteomics LC-MS/MS approaches

Discovery-based proteomics

Proteomics

Biogenity offers global protein analysis of your samples, getting deep proteome coverages with state-of-the-art accuracy.

Learn more
Phosphoproteomics

Proteomics

Biogenity can provide you with deep coverage and an easy-to-follow report if you are interested in kinase activity and phosphorylation patterns.

Learn more
Gel bands

Proteomics

If you have identified interesting gel bands, Biogenity can perform in-gel digestion and identify your protein(s).

Learn more
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Degradomics in the R&D field

Degradomics have shown great relevance in both precision medicine and system biology. Degradomics can be explored for vast opportunities. The protease modulatory web provides a unique opportunity to discover novel disease biomarkers and potential drug targets. Controlling proteolytic processing offers precise control of several biological processes:

Proteolytic processing relevant biological processes:

  • Cell-cycle progression
  • Angiogenesis
  • Cell cycle
  • Apoptosis
  • Cell proliferation
  • DNA replication
  • Immunity
  • Wound healing