Animal-based proteomics

Proteome analysis


Animals can be separated into six different types: mammals, birds, amphibians, reptiles, and invertebrates. All are multicellular eukaryotic organism and contains complex and fascinating biological systems. The utilities of animals in research are vast, such as animal models of complex diseases and the study of feed degradation and digestion. Having a central role in research, diagnostics, therapeutics, and the food industry, we must get the most information from each sample, especially to follow the 3R principles (Replace, Reduce, Refine) for research and testing involving animals.

If you’d like to learn more, we are happy to discuss your project and help you get the most out of your animal samples.


Let’s discuss your project

Guiding you from sample to biology

Our experts are ready to help you with your animal-based proteomics project. Ideally, we set up an online meeting where we get to learn about your project. Here, we discuss the different options to reach your aim.



Get a price estimate within 24 hours

If you need an estimate for your project, we are happy to help. We encourage you to request an initial free consultation to assess which approach fits your research aim.



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Sample preparation and Mass Spectrometry

A tailored workflow for animal-based proteomics analysis

When working with animals, it is essential to understand which type of information can be expected from different sample types, like tissue, blood, and plasma, to get the maximum outcome of each study. We can guide you to understand the proteomics output, the availability, and the utilities hereof. The power calculation is also essential to ensure a significant output of the study and that no samples are wasted. If you are unsure about your power calculation, feel free to contact us - our scientists are ready to guide you.



Various approaches for sample preparation

The different types of animals and diverse samples make it important to select the correct approach that fits the samples. At Biogenity, we offer a wide range of Standard Operating Procedures (SOP), ensuring the approach is adjusted to the sample to retrieve the proteome. You will, of course, get the SOPs used for your project, so you know precisely how your samples have been processed.

The latest equipment from Thermo Fisher Scientific

We pride ourselves on being able to offer the latest equipment on the market. Our collaborating proteomics laboratory has the latest equipment from Thermo Fisher, ensuring a deep coverage. If you’d like to see the complete platform list, follow this link.



The correct mass spectrometer for the job

The complexity of the animal samples is source-dependent. We provide you with different instrument options, ensuring that we find the correct mass spectrometer for the job. The mass spectrometer options are orbitrap-based from Thermo Fisher Scientific, ranging from the Q Exactive Classic to the Eclipse Tribrid and the Exploris 480. Our most sensitive workflows provide:

  • +10,000 proteins in cell studies
  • 2,000 proteins in plasma studies
  • 3,000 proteins from a 1*106 micron laser microdissected tissues studies

Data analysis, including report, figures, and tables

Visualization of your animal-based analysis

Data analysis is where you get the overview of your animal-based analysis. You will receive an easy-to-follow report describing the data analysis and results hereof, step-by-step, together with a folder containing all tables and figures. To ensure that you have the material needed, we always provide a vast number of figures and tables.



Data analysis for animal-based proteomics

Biogenity provides vastly different data analysis options to tailor the analysis to your research aims and bring forward what is essential. We do everything from data filtering, batch effect removal, outlier check to statistics, bioinformatics, and biological modeling.

Network mapping of pathways, interactive plots, and more

Discover the biology with our network mapping of pathways, biological processes, molecular functions, and cellular components to find potential signal routes, and discover where your study's effect is present. Here, you can get an overview of the individual pathways with our interactive plots, where you can see how the proteins interact and isolate the key components of interest. You can also uncover the power of Machine- and Deep Learning (AI) and get our experts to generate your models to, e.g., create new diagnostic and prognostic tools.

Delivery and discussion

Delivered directly to your inbox

When your animal-based proteomics analysis is ready, we deliver it directly to your inbox. Your data and reports are easy to access and secured with encryption and password protection.

You can receive your sample leftovers sent by courier, or Biogenity can safely destroy them after project completion. It is entirely up to you.



Plant a tree with Biogenity and One Tree Planted

Partnering with One Tree Planted, we want to work towards a brighter future with better treatment for diseases and a healthy planet to enjoy life. For us, our children, grandchildren, and the generations to come.

Biogenity donates a dozen trees for every project delivered to support local communities, reforestation in the Amazon rainforest, and reduce CO2 emissions. See how we are making a difference together.

Post-consultation and discussion

It is important to us that you get the most out of your experiment, which is why we always offer a post-consultation where you can ask all your questions about the results. Together, we ensure that you have the best prerequisite for your further research. The consultation can also be used to explore the next step, whether you are looking to expand the project with additional omics studies or validate the results.

What you can expect:

  • Explanation of the different steps in the sample analysis
  • Discussion of the data
  • Explanation of the different steps in the data analysis
  • Q&A to the report

Other proteomics LC-MS/MS approaches

Laser microdissection

Proteomics

Utilizing laser microdissection, Biogenity provides high-sensitivity proteomics with up to 3,000 proteins from 10^6 micron tissue pieces.

Learn more
Discovery-based proteomics

Proteomics

Biogenity offers global protein analysis of your samples, getting deep proteome coverages with state-of-the-art accuracy.

Learn more
Phosphoproteomics

Proteomics

Biogenity can provide you with deep coverage and an easy-to-follow report if you are interested in kinase activity and phosphorylation patterns.

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