In drug development, understanding how mature and newly produced proteins are affected by drugs is vital to elucidate the potential effects of the drug and to determine the specificity of the drug by only targeting the proteins of interest. Proteome Dynamics Profiling provides a reliable overview of the proteins affected by your intervention.
By utilizing Stable Isotope Labeling by Amino acids in Cell culture (SILAC) in drug development studies, it is possible to determine which proteins are mature when adding a drug and which are newly produced. By tracking how the proteins are affected, we can determine which mature proteins are degraded or stabilized. Similarly, by tracking the newly produced proteins, we can determine which proteins demonstrate an enhanced or reduced production following the application of the drug.
Proteome Dynamics Profiling is an excellent choice for early verification of potential drug candidates or other interventions. The distinction between mature and nascent proteins gives a more granular overview than ordinary global proteomics experiments.
We are happy to discuss how this technology can be applied to your experiments and help you get actionable data on your drug candidates.
Our team of experts is prepared to assist you with your research. We can arrange an online meeting to understand your project better and discuss various options to help you achieve your goals.
At Biogenity, we understand that performing new assays are complex. As a part of our Proteome Dynamics Profiling workflow, we ensure that you understand all the steps along the way and provide guidance and protocols as needed.
If you need an estimate for your project, we are happy to help. We encourage you to request an initial free consultation to assess which proteomics approach fits your research aim.
Biogenity's team is experienced in working with different approaches, and we always offer a free consultation to discuss how dynamic proteome profiling or other workflows fit your research aim. At Biogenity, we care, which is why it is essential for us to understand your study to ensure that we provide you with the best approach for your research.
Biogenity's team and partners consist of specialized personnel ensuring your samples get quality handling. We offer partial and complete sample preparation workflows and always share our protocols to ensure transparency. While we are happy to accommodate your sample preparation, we highly recommend that Biogenity conduct most of the sample preparation to minimize variance.
At Biogenity, we take pride in providing state-of-the-art equipment for your proteomics research needs. Our collaborating proteomics laboratory is equipped with the latest instruments from Thermo Fisher Scientific to ensure deep coverage of your samples. If you want to see the complete platform list, follow this link.
The Orbitrap Eclipse Tribrid mass spectrometer combined with FAIMS and Evosep One provides a fast and robust workflow, enabling us to monitor up to 10,000 proteins across your samples. Hence, you get a deep understanding of how even low-abundant proteins are affected by your intervention.
At Biogenity, we know that data analysis is crucial to understanding the impact of your intervention. That's why we provide you with an easy-to-follow report detailing the reliably and significantly changing proteins. We walk you through the figures step-by-step, together with a folder containing all tables and figures.
Biogenity's data analysis can be tailored to different research aims, from machine learning and statistics on biomarkers to validating peptide spectra, uncovering new mutations, and establishing degradation motifs. We always strive to provide you with the right tools to understand the data and communicate your findings.
With Biogenity's advanced bioinformatic data analysis services, you can gain a deeper understanding of your proteome dynamics profiling data for drug Development. Our interactive plots highlight enriched signaling pathways and allow you to explore regulated proteins in a biological context. We also provide comprehensive enrichment analysis, comparative figures, and network mapping to identify changes in pathways, biological processes, molecular functions, cellular components, and kinases in your biological fluids. Trust Biogenity to provide you with accurate and detailed insights into your proteomics data.
At Biogenity, we understand that quick access to your proteome dynamics profiling data for drug development is essential. That's why we deliver your comprehensive reports and results directly to your inbox. Our encrypted and password-protected system ensures that your data remains secure and accessible only to you.
You can receive your sample leftovers sent by courier, or Biogenity can safely discard them after project completion. It is entirely up to you.
Partnering with One Tree Planted, we want to work towards a brighter future with better treatment for diseases and a healthy planet to enjoy life. For us, our children, grandchildren, and the generations to come.
At Biogenity, we strive for more than just scientific advancements. We donate a dozen trees for every project delivered to support local communities, promote reforestation in the Amazon rainforest, and reduce CO2 emissions. See how we are making a difference together.
At Biogenity, we value your research goals and strive to provide you with the best results possible. After the analysis, we offer a thorough post-consultation to discuss and answer any questions you may have regarding the results. This enables us to ensure that you have a clear understanding of the analysis and results, giving you a strong foundation for further research. Moreover, we use this consultation to explore potential next steps, such as expanding your project with additional omics studies or validating the findings.
During the consultation, we can provide the following:
Application and purposes with proteome dynamics profiling in drug development
Proteomics covers various disciplines for investigating proteins. The different approaches to proteomic research have numerous applications and purposes:
Processes regulated by proteins
Types of proteomics: