Proteome dynamics profiling for Drug Development

Proteome analysis

In drug development, understanding how mature and newly produced proteins are affected by drugs is vital to elucidate the potential effects of the drug and to determine the specificity of the drug by only targeting the proteins of interest. Proteome Dynamics Profiling provides a reliable overview of the proteins affected by your intervention.

By utilizing Stable Isotope Labeling by Amino acids in Cell culture (SILAC) in drug development studies, it is possible to determine which proteins are mature when adding a drug and which are newly produced. By tracking how the proteins are affected, we can determine which mature proteins are degraded or stabilized. Similarly, by tracking the newly produced proteins, we can determine which proteins demonstrate an enhanced or reduced production following the application of the drug.

Proteome Dynamics Profiling is an excellent choice for early verification of potential drug candidates or other interventions. The distinction between mature and nascent proteins gives a more granular overview than ordinary global proteomics experiments.

We are happy to discuss how this technology can be applied to your experiments and help you get actionable data on your drug candidates.

Let’s discuss your project

Customized sample preparation for proteome dynamics profiling in drug development

Biogenity's team is experienced in working with different approaches, and we always offer a free consultation to discuss how dynamic proteome profiling or other workflows fit your research aim. At Biogenity, we care, which is why it is essential for us to understand your study to ensure that we provide you with the best approach for your research.

Experienced professionals

Biogenity's team and partners consist of specialized personnel ensuring your samples get quality handling. We offer partial and complete sample preparation workflows and always share our protocols to ensure transparency. While we are happy to accommodate your sample preparation, we highly recommend that Biogenity conduct most of the sample preparation to minimize variance.

Cutting-edge Mass Spectrometers for accurate protein analysis

At Biogenity, we take pride in providing state-of-the-art equipment for your proteomics research needs. Our collaborating proteomics laboratory is equipped with the latest instruments from Thermo Fisher Scientific to ensure deep coverage of your samples. If you want to see the complete platform list, follow this link.

State-of-the-art equipment for your research needs

The Orbitrap Eclipse Tribrid mass spectrometer combined with FAIMS and Evosep One provides a fast and robust workflow, enabling us to monitor up to 10,000 proteins across your samples. Hence, you get a deep understanding of how even low-abundant proteins are affected by your intervention.

Delivered directly to your inbox

At Biogenity, we understand that quick access to your proteome dynamics profiling data for drug development is essential. That's why we deliver your comprehensive reports and results directly to your inbox. Our encrypted and password-protected system ensures that your data remains secure and accessible only to you.

You can receive your sample leftovers sent by courier, or Biogenity can safely discard them after project completion. It is entirely up to you.

Plant a tree with Biogenity and One Tree Planted

Partnering with One Tree Planted, we want to work towards a brighter future with better treatment for diseases and a healthy planet to enjoy life. For us, our children, grandchildren, and the generations to come.

At Biogenity, we strive for more than just scientific advancements. We donate a dozen trees for every project delivered to support local communities, promote reforestation in the Amazon rainforest, and reduce CO₂ emissions. See how we are making a difference together.

In-depth consultation and analysis discussion

At Biogenity, we value your research goals and strive to provide you with the best results possible. After the analysis, we offer a thorough post-consultation to discuss and answer any questions you may have regarding the results. This enables us to ensure that you have a clear understanding of the analysis and results, giving you a strong foundation for further research. Moreover, we use this consultation to explore potential next steps, such as expanding your project with additional omics studies or validating the findings.

During the consultation, we can provide the following:

• Detailed explanation of the sample analysis process
• Discussion of the data obtained from the analysis
• Explanation of the different steps in the data analysis
• Q&A session to address any queries you may have about the report